Immunogenetics of Hematopoietic Stem Cell Transplantation
نویسندگان
چکیده
The first bone marrow transplantation took place in 1949 with studies that demonstrated the protection provided to the spleen of mice given a dose of irradiation that would otherwise be lethal. In 1960, studies in dogs provided important information about bone marrow transplantation in exogamic species, results that are applicable to humans. It was demon‐ strated that dogs could bear 2-3 times the lethal dose of total body irradiation with an infu‐ sion of bone marrow cells collected and cryopreserved before irradiation [2,3].
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